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22-250 Ammo For Sale

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The 22-250 Remington is a high-velocity, flat-shooting centerfire cartridge known for exceptional long-range accuracy and blistering speeds that often exceed 3,500 fps. Now in stock, we offer a wide selection of 22-250 ammo from trusted manufacturers. Learn More

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Overview of 22-250 Ammo

The .22-250 Remington cartridge was developed in 1937 as a collaboration between Grosvenor Wotkyns, J.E. Gebby, and J.E. Smith as a long-range (400 yards) varmint hunting cartridge. he .22-250 Remington was no stranger to military service in the 1980s. The Australian Special Air Service employed this cartridge for urban sniping operations to decrease the risk of ricochet and over-penetration.

The .22-250 maintains its popularity due to its excellent accuracy and mild recoil. It is widely available at price points similar to those of other .22 caliber centerfire ammo. It performs well for various applications over wide ranges and is ridiculously consistent. A gun writer once wrote that the cartridge was “boringly accurate,” referencing the round's predictable performance—indeed, no insult for this excellent varmint cartridge.

What Is 22-250 Ammo Best For?

The 22-250 Remington is best known as a premier varmint and predator cartridge. It’s a top choice for coyotes, prairie dogs, groundhogs, and similar small to mid-sized game where flat shooting and precision matter. In open country such as farm fields, prairie, and wide Western terrain, it gives hunters the consistency needed to make clean, ethical shots at extended distances.

It is ideal for shooters who want a fast, accurate centerfire round that excels in long-range small game applications rather than traditional big game hunting.

How Does The 22-250 Rem Compare To Other Calibers?

Caliber Recoil Pros Cons
204 Ruger 22-250 Rem has more 22-250 Rem has more stopping power and more abundant ammo selection 22-250 Rem has slightly heavier recoil and worse trajectory
223 Remington 22-250 Rem has more 22-250 Rem has more stopping power and flatter trajectory 22-250 Rem has slightly heavier recoil and more expensive ammo
22 Nosler 22-250 Rem has slightly more 22-250 Rem has flatter trajectory and more ammo options 22-250 Rem has slightly heavier recoil and less than ideal for deer hunting
224 Valkyrie Nearly identical 22-250 Rem has better short-range trajectory and better for hunting 22-250 Rem has worse long-range trajectory and slightly more expensive ammo

You can also check out our in-depth look at 22 250 ballistics from all of the popular ammo manufacturers if you're searching for ballistics data for your favorite factory 22-250 load.

Molly Carter
Written by
Molly Carter